Exploring Testing Applications of the CAM Assay

Laboratory Test Request Description

Number: 23-02129

Industry: Pharmaceuticals

Biotech Company needs Pharmaceutical Laboratory for pharmaceutical compound anti-angiogenesis activity study for and to comparison to reference drug Avastin by Membrane (CAM) Assay

The CAM assay, or Chorioallantoic Membrane assay, is a technique in biological research that involves the using a developing chicken embryo for experimental purposes. The chorioallantoic membrane is a highly vascularized structure that surrounds the developing chicken embryo. Because of this, chorioallantoic membrane assays provide a way to study processes like angiogenesis (formation of blood vessels), tumor growth, and drug diffusion. The CAM assay method involves applying test substances like drugs or compounds, onto the surface of the chorioallantoic membrane. Researchers can then observe and quantify the effects of the chosen substance targeted developmental function. This method is particularly useful due to its low cost, high throughput nature, and ethical considerations when compared to traditional animal models.

The CAM assay can be applied in a wide range of fields, such as cancer research, pharmacology, and developmental biology. In cancer research, this assay helps to evaluate potential anti-angiogenic effects of drugs by assessing their impact on blood vessel formation, which is crucial for tumor growth. In drug development, researchers can use a CAM assay to study the way that different pharmaceutical compounds are diffused and distributed in the embryo, which can help in understanding their performance and potential side effects. Additionally, the assay can also be used to investigate embryonic development, wound healing, and tissue regeneration. Its versatility and accessibility have made the CAM assay an a very useful tool in advancing our understanding of various biological processes and accelerating scientific discoveries.