The Need for Lab Experts in Coagulation, Complement, and Genetics
Machaon Diagnostics Founder and CEO Michael Ero joins us to discuss some of the challenges and successes of working with rare disease studies in this Ask the Expert exclusive.
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Genetics & Genomics
The Differences Between Cell Therapy and Gene Therapy
Cell Therapy and Gene Therapy Research and Development Cell and gene therapy are similar fields of biomedical research aimed at treating genetic diseases and are often combined in treatment. Cell therapy was introduced in the 1940s during the first blood...
Immunogenicity of Biologics
The US Food and Drug Administration defines biologics as "a wide range of products such as vaccines, blood and blood components, allergenics, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins...composed of sugars, proteins, or nucleic acids...
Residual DNA Testing | Host Cell DNA Analysis
Residual DNA testing, or host cell DNA analysis, is the examination of products for traces of DNA that have been unintentionally left on a product during the manufacturing of biological products such as biosimilars or immunotherapeutic products. For customer health...
Pharmacogenetics Testing | Precision Medicine Testing
Pharmacogenetics is a branch of science that studies how a person's genetics influence their response to pharmaceuticals (read an entry to pharmacogenetics, here). Adverse Drug Reactions (ADRs) are one of the biggest influences in the study of pharmacogenetics, as...
Proteomic Profile Techniques
Proteomics is a part of molecular biology that studies proteins. A proteome is a set of proteins that are either produced or modified by an organism and proteomics helps us understand things like the structure and function of the protein in an organism. The first...
Bacteria Whole Genome Sequencing (WGS) | Pulsed-Field Gel Electrophoresis (PFGE)
How PFGE and WGS are used to detect illness outbreaks? DNA fingerprinting is often performed on bacteria isolated from people who are sick by using techniques called pulsed-field gel electrophoresis (PFGE) and whole-genome sequencing (WGS). These techniques provide...
Liposome Research and Testing
Looking for liposome research? According to the US Food and Drug Administration (USFDA) Guidance Document entitled "Liposome Drug Products", a liposome is a microvesicle composed of a bilayer of lipid amphipathic molecules enclosing an aqueous compartment. It...
What is CRISPR?
CRISPR is said to be "an easy, cheap, and very precise way to edit the DNA of living cells". It's said to be a "game-changer" in genetic engineering. CRISPR is an acronym that stands for Clustered Regularly Interspaced Short Palindromic Repeat. CRISPR technology...
Genotyping
Genotyping is a process used to obtain DNA information, specifically used to determine the genetic variants or differences an individual has. Common genotyping methods include restriction fragment length polymorphism identification of genomic DNA, polymerase chain...
Pharmacogenetics
Pharmacogenetics is the study of how genetic differences affect a person's response to medicine. Pharmacogenetics is often used interchangeably with pharmacogenomics. Pharmacogenetic research and testing determine a person's ability to metabolize medicines and...
Polymerase Chain Reaction (PCR) Analysis and Testing
What is Polymerase Chain Reaction Testing? PCR stands for Polymerase Chain Reaction and may be called "molecular photocopying," as it's a technique used to "amplify," or copy, DNA segments. According to the National Institutes of Health's National Human Genome...
Women in Science | Barbara McClintock
Barbara McClintock was born June 16, 1902 in Hartford, Connecticut. During high school, she developed a love of science and was determined to continue her studies at Cornell University studying agriculture, and in 1923, she received her BS in botany. McClintock...
What are Genetically Modified Organisms (GMO) Foods?
Genetically Modified Organisms (GMO) foods are created in a laboratory through genetic modification and engineering. Non-Genetically Modified Organisms (Non-GMO) foods are those that have not been genetically modified. Many concerns regarding the safety of GMOs...
What is DNA Purification?
DNA purification, a cornerstone technique in molecular biology, is a process designed to extract and purify DNA from various biological samples. This crucial procedure not only facilitates the isolation of DNA but also ensures its purity, making it suitable for a...
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Navigating the Path to Green: The Laboratory’s Role in EPA Product Certification
Discover the blend of science and sustainability that ensures products are...
Let’s Talk About Workplace Safety: Insights from a Senior Safety Editor
From safety culture to a culture of safety, protecting workers from harm is...
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